Detail Information
P450 Protein:
| P450 Symbol | CPR |
| Protein Name | NADPH--cytochrome P450 reductase |
| Uniprot ID | Q05001 |
| EC Number | 1.6.2.4 |
| Species | Catharanthus roseus |
| Txid | 4058 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C16H12O5 → C16H12O7 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Ethanol, Water |
| Conditions | overnight, rt |
| Transformations | 1. Hydroxylation at an Aliphatic Carbon |
CPR
Substrate Information:
| Substrate Name | (-)-Maackiain |
| Substrate Chemical Formula | C16H12O5 |
| Substrate PubChem CID | 91510 |
| Substrate Smiles | C1C2C(C3=C(O1)C=C(C=C3)O)OC4=CC5=C(C=C24)OCO5 |
| Substrate Structure |
Product Information:
| Product Name | trans-6,6a-Dihydroxymaackiain |
| Product Chemical Formula | C16H12O7 |
| Product PubChem CID | 101709616 |
| Product CAS Number | 193681-07-1 |
| Product Smiles | OC1=CC=C2C(OC(O)C3(O)C4=CC=5OCOC5C=C4OC23)=C1 |
| Product Structure |
References:
| Title: | Oxidation of the phytoalexin maackiain to 6,6-dihydroxy-maackiain by Colletotrichum gloeosporioides. |
| PMID: | 9214775 |
| Journal: | Phytochemistry (1997) |
| Year: |