Detail Information
P450 Protein:
| P450 Symbol | CYP17A1 |
| Protein Name | Steroid 17-alpha-hydroxylase/17,20 lyase |
| Uniprot ID | P05185 |
| EC Number | 1.14.14.19 |
| Gene ID | 281739 |
| Species | Bos taurus |
| Txid | 9913 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C19H28O2 → C19H28O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Water |
| Transformations | 1. Hydroxylation at an Aliphatic Carbon |
CYP17A1
Substrate Information:
| Substrate Name | Testosterone |
| Substrate Chemical Formula | C19H28O2 |
| Substrate PubChem CID | 6013 |
| Substrate Smiles | CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C |
| Substrate Structure |
Product Information:
| Product Name | 6beta-Hydroxytestosterone |
| Product Chemical Formula | C19H28O3 |
| Product PubChem CID | 65543 |
| Product CAS Number | 62-99-7 |
| Product Smiles | CC12CCC3C(C1CCC2O)CC(C4=CC(=O)CCC34C)O |
| Product Structure |
References:
| Title: | The use of electrochemistry for the synthesis of 17 alpha-hydroxyprogesterone by a fusion protein containing P450c17. |
| PMID: | 8969926 |
| Journal: | Endocrine Research (1996) |
| Year: |