Detail Information
P450 Protein:
| P450 Symbol | Cyp2b1 |
| Protein Name | Cytochrome P450 2B1 |
| Uniprot ID | P00176 |
| EC Number | 1.14.14.1 |
| Gene ID | 24300 |
| Species | Rattus norvegicus |
| Txid | 10116 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C21H24O6 → C20H22O6 |
| Reaction Type | Oxidation |
| Chemical Bond | OCH3 |
| Solvents | Dimethyl sulfoxide, Water |
| Conditions | 3 d, 37°C |
| Transformations | 1. Formation of Alkyl Halides/ Alcohols from Ethers /Silyl Ethers |
Cyp2b1
Substrate Information:
| Substrate Name | (-)-Arctigenin |
| Substrate Chemical Formula | C21H24O6 |
| Substrate PubChem CID | 64981 |
| Substrate Smiles | COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC |
| Substrate Structure |
Product Information:
| Product Name | 3-O-Demethylarctigenin |
| Product Chemical Formula | C20H22O6 |
| Product PubChem CID | 384870 |
| Product CAS Number | 147022-95-5 |
| Product Smiles | O=C1OCC(CC2=CC=C(OC)C(OC)=C2)C1CC3=CC=C(O)C(O)=C3 |
| Product Structure |
References:
| Title: | Biotransformation of the naturally occurring lignan (-)-arctigenin in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms. |
| PMID: | 7997474 |
| Journal: | Planta Medica (1994) |
| Year: |