Detail Information

P450 Protein:

P450 SymbolCYP101A1
Protein NameCamphor 5-monooxygenase
Uniprot IDP00183
EC Number1.14.15.1
Gene ID 9617760
SpeciesPseudomonas putida
Txid 303
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C11H16O → C11H16O2
Reaction TypeOxidation
Chemical BondC=C
Transformations1. Epoxidation of Alkenes

(1R,4S)-1,7,7-Trimethyl-5-methylenebicyclo[2.2.1]heptan-2-one

CYP101A1

Spiro[bicyclo[2.2.1]heptane-2,2′-oxiran]-5-one, 4,7,7-trimethyl-, [1R-(1alpha,2alpha,4alpha)]

Substrate Information:

Substrate Name (1R,4S)-1,7,7-Trimethyl-5-methylenebicyclo[2.2.1]heptan-2-one
Substrate Chemical FormulaC11H16O
Substrate PubChem CID101237419
Substrate SmilesO=C1CC2C(=C)CC1(C)C2(C)C
Substrate Structure

Product Information:

Product Name Spiro[bicyclo[2.2.1]heptane-2,2′-oxiran]-5-one, 4,7,7-trimethyl-, [1R-(1alpha,2alpha,4alpha)]
Product Chemical FormulaC11H16O2
Product CAS Number154614-04-7
Product SmilesO=C1CC2C3(OC3)CC1(C)C2(C)C
Product Structure

References:

Title: The syntheses of 1R- and 1S-5-methylenylcamphor and their epoxidation by cytochrome P-450-CAM
DOI: https://doi.org/10.1016/0040-4020(93)80022-L
Journal: Tetrahedron
Year: 1905/6/15

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
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