Detail Information
P450 Protein:
| P450 Symbol | Cyp1a2 |
| Protein Name | Cytochrome P450 1A2 |
| Uniprot ID | P04799 |
| EC Number | 1.14.14.1 |
| Gene ID | 24297 |
| Species | Rattus norvegicus |
| Txid | 10116 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C8H9NO → C8H9NO2 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Transformations | 1.Hydroxylation of Aromatic Compounds 2.Hydroxylation at an Aromatic Carbon |
Cyp1a2
Substrate Information:
| Substrate Name | Acetanilide |
| Substrate Chemical Formula | C8H9NO |
| Substrate PubChem CID | 904 |
| Substrate Smiles | CC(=O)NC1=CC=CC=C1 |
| Substrate Structure |
Product Information:
| Product Name | 2-Acetamidophenol |
| Product Chemical Formula | C8H9NO2 |
| Product PubChem CID | 11972 |
| Product CAS Number | 614-80-2 |
| Product Smiles | CC(=O)NC1=CC=CC=C1O |
| Product Structure |
References:
| Title: | Mutations at the distal and proximal sites of cytochrome P-450d changed regio-specificity of acetanilide hydroxylations. |
| PMID: | 2719689 |
| Journal: | Biochemical and Biophysical Research Communications (1989) |
| Year: | 1989/4/28 |