Detail Information
P450 Protein:
| P450 Symbol | POR |
| Protein Name | NADPH--cytochrome P450 reductase |
| Uniprot ID | P00389 |
| EC Number | 1.6.2.4 |
| Gene ID | 100301554 |
| Species | Oryctolagus cuniculus |
| Txid | 9986 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C27H44O2 → C27H44O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Transformations | 1. Hydroxylation at an Aliphatic Carbon |
POR
Substrate Information:
| Substrate Name | Alfacalcidol |
| Substrate Chemical Formula | C27H44O2 |
| Substrate PubChem CID | 5282181 |
| Substrate Smiles | CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C |
| Substrate Structure |
Product Information:
| Product Name | Calcitriol |
| Product Chemical Formula | C27H44O3 |
| Product PubChem CID | 5280453 |
| Product CAS Number | 32222-06-3 |
| Product Smiles | CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C |
| Product Structure |
References:
| Title: | 25-Hydroxylation of vitamin D3 by a cytochrome P-450 from rabbit liver mitochondria. |
| PMID: | 2844144 |
| Journal: | Biochemical Journal (1988) |
| Year: | 1988/5/15 |