Detail Information
P450 Protein:
| P450 Symbol | BcmD |
| Protein Name | Cytochrome |
| Uniprot ID | A0A2G1XAS5 |
| Species | Streptomyces cinnamoneus |
| Txid | 53446 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C12H20N2O6 → C12H20N2O7 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Conditions | pH 7.5, 30°C |
| Transformations | 1. Hydroxylation at an Aliphatic Carbon |
BcmD
Substrate Information:
| Substrate Name | 2-Oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione, 5-methyl-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-, (1S,6S)- (ACI) |
| Substrate Chemical Formula | C12H20N2O6 |
| Substrate Smiles | O=C1NC2(OCCC(C)C1NC2=O)C(O)C(O)(C)CO |
| Substrate Structure |
Product Information:
| Product Name | Bicyclomycin, 4,11-dihydro- (9CI) |
| Product Chemical Formula | C12H20N2O7 |
| Product PubChem CID | 6451698 |
| Product CAS Number | 41238-48-6 |
| Product Smiles | O=C1NC2(OCCC(C)C1(O)NC2=O)C(O)C(O)(C)CO |
| Product Structure |
References:
| Title: | A Six-Oxidase Cascade for Tandem C-H Bond Activation Revealed by Reconstitution of Bicyclomycin Biosynthesis. |
| PMID: | 29194897 |
| Journal: | Angewandte Chemie, International Edition |
| Year: | 2017/11/30 |