Detail Information
P450 Protein:
| P450 Symbol | txtC |
| Protein Name | Cytochrome P450 |
| Uniprot ID | Q8VS75 |
| Species | Streptomyces acidiscabies |
| Txid | 42234 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C11H11FN2O2 + CH4O → C22H22FN3O4 |
| Reaction Type | Oxidation |
| Chemical Bond | |
| Conditions | 5 - 7 d, 28°C |
| Transformations | 1.Replacement of a Hydroxy/ Alkoxy/ Acyloxy by Nitrogen Nucleophiles 2.Hydroxylation of Aromatic Halides 3.Acylation of Nitrogen Nucleophiles by Carboxylic Acids |
+
txtC
Substrate Information:
| Substrate Name | 4-Fluoro-L-tryptophan |
| Substrate Chemical Formula | C11H11FN2O2 |
| Substrate PubChem CID | 101198 |
| Substrate Smiles | O=C(O)C(N)CC1=CNC=2C=CC=C(F)C21 |
| Substrate Structure |
| Substrate Name | Methanol |
| Substrate Chemical Formula | CH4O |
| Substrate PubChem CID | 887 |
| Substrate CAS Number | 67-56-1 |
| Substrate Smiles | OC |
| Substrate Structure |
Product Information:
| Product Name | 2,5-Piperazinedione, 6-[(4-fluoro-1H-indol-3-yl)methyl]-3-hydroxy-3-[(3-hydroxyphenyl)methyl]-1,4-dimethyl-, (3R,6S)- (ACI) |
| Product Chemical Formula | C22H22FN3O4 |
| Product CAS Number | 2231090-12-1 |
| Product Smiles | O=C1N(C)C(O)(C(=O)N(C)C1CC2=CNC=3C=CC=C(F)C32)CC=4C=CC=C(O)C4 |
| Product Structure |
References:
| Title: | De novo Biosynthesis of ""Non-Natural"" Thaxtomin Phytotoxins. |
| PMID: | 29603527 |
| Journal: | Angewandte Chemie, International Edition |
| Year: | 2018/6/4 |