Detail Information

P450 Protein:

P450 SymboljuvC
Protein NameCytochrome P450 hydroxylase
Uniprot IDA0A1Z1MZ61
SpeciesMicromonospora chalcea subsp. izumensis
Txid 2008351
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C31H53NO8 → C31H53NO9
Reaction TypeOxidation
Chemical BondCH
SolventsDimethyl sulfoxide;Water
Conditionsovernight, pH 7.3, 30°C
TransformationsEpoxidation of Alkenes

Cirramycin A1, 12,13-deepoxy-12,13-didehydro-20-deoxo-4-deoxy-20-hydroxy- (9CI, ACI)

juvC

Cirramycin A1, 20-deoxo-4′-deoxy-20-hydroxy- (9CI, ACI)

Substrate Information:

Substrate Name Cirramycin A1, 12,13-deepoxy-12,13-didehydro-20-deoxo-4-deoxy-20-hydroxy- (9CI, ACI)
Substrate Chemical FormulaC31H53NO8
Substrate PubChem CID3042013
Substrate SmilesO=C1OC(CC)C(C=C(C=CC(=O)C(C)CC(CCO)C(OC2OC(C)CC(N(C)C)C2O)C(C)C(O)C1)C)C
Substrate Structure

Product Information:

Product Name Cirramycin A1, 20-deoxo-4′-deoxy-20-hydroxy- (9CI, ACI)
Product Chemical FormulaC31H53NO9
Product PubChem CID71425
Product CAS Number61475-37-4
Product SmilesO=C1OC(CC)C(C)C2OC2(C=CC(=O)C(C)CC(CCO)C(OC3OC(C)CC(N(C)C)C3O)C(C)C(O)C1)C
Product Structure

References:

Title: Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.
PMID: 28525276
Journal: Journal of the American Chemical Society
Year: 2017/6/5

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics