Detail Information
P450 Protein:
| P450 Symbol | juvD |
| Protein Name | Cytochrome P450 epoxidase |
| Uniprot ID | A0A1Z1MZ59 |
| Species | Micromonospora chalcea subsp. izumensis |
| Txid | 2008351 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C31H53NO7 → C31H53NO8 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Dimethyl sulfoxide;Water |
| Conditions | overnight, pH 7.3, 30°C |
| Transformations | Hydroxylation at an Aliphatic Carbon |
juvD
Substrate Information:
| Substrate Name | Tylonolide, 20-deoxo-23-deoxy-5-O-[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]- (9CI, ACI) |
| Substrate Chemical Formula | C31H53NO7 |
| Substrate PubChem CID | 73188495 |
| Substrate Smiles | O=C1OC(CC)C(C=C(C=CC(=O)C(C)CC(CC)C(OC2OC(C)CC(N(C)C)C2O)C(C)C(O)C1)C)C |
| Substrate Structure |
Product Information:
| Product Name | Tylonolide, 20-deoxo-5-O-[3,4,6-trideoxy-3-(dimethylamino)-bata-D-xylo-hexopyranosyl]- (9CI, ACI) |
| Product Chemical Formula | C31H53NO8 |
| Product PubChem CID | 163051724 |
| Product CAS Number | 87092-82-8 |
| Product Smiles | O=C1OC(CC)C(C=C(C=CC(=O)C(C)CC(CC)C(OC2OC(C)CC(N(C)C)C2O)C(C)C(O)C1)C)CO |
| Product Structure |
References:
| Title: | Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization. |
| PMID: | 28525276 |
| Journal: | Journal of the American Chemical Society |
| Year: | 2017/6/5 |