Detail Information
P450 Protein:
| P450 Symbol | pntM |
| Protein Name | Pentalenolactone synthase |
| Uniprot ID | E3VWI3 |
| EC Number | 1.14.19.8 |
| Species | Streptomyces arenae |
| Txid | 29301 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C15H18O5 → C15H16O5 |
| Reaction Type | Oxidation |
| Chemical Bond | |
| Solvents | Tetrahydrofuran;Water |
| Conditions | 4 h, pH 8, 30°C |
pntM
Substrate Information:
| Substrate Name | / |
| Substrate Chemical Formula | C15H18O5 |
| Substrate PubChem CID | 73097470 |
| Substrate Smiles | O=C(O)C1=CC2CC(C)(C)CC23C1COC(=O)C43OC4 |
| Substrate Structure |
Product Information:
| Product Name | 7,8-dimethyl-2-oxospiro[4,4a,6a,7-tetrahydropentaleno[1,6a-c]pyran-1,2′-oxirane]-5-carboxylic acid |
| Product Chemical Formula | C15H16O5 |
| Product PubChem CID | 282522 |
| Product CAS Number | 31501-48-1 |
| Product Smiles | O=C(O)C1=CC2C(C(=CC23C1COC(=O)C43OC4)C)C |
| Product Structure |
References:
| Title: | The Cytochrome P450-Catalyzed Oxidative Rearrangement in the Final Step of Pentalenolactone Biosynthesis: Substrate Structure Determines Mechanism. |
| PMID: | 27588339 |
| Journal: | Journal of the American Chemical Society |
| Year: | 2016/9/2 |