Detail Information
P450 Protein:
| P450 Symbol | CYP106A2 |
| Protein Name | Steroid 15-beta-monooxygenase |
| Uniprot ID | Q06069 |
| EC Number | 1.14.15.8; 1.14.99.- |
| Species | Bacillus megaterium ATCC 13368 |
| Txid | 1404 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C21H30O2 → C21H30O3 + C21H30O3 + C21H30O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
| Solvents | Isopropanol, Water |
| Conditions | 1 h, pH 8, 25°C |
| Transformations | Hydroxylation at an Aliphatic Carbon |
CYP106A2
+
+
Substrate Information:
| Substrate Name | Progesterone |
| Substrate Chemical Formula | C21H30O2 |
| Substrate PubChem CID | 5994 |
| Substrate Smiles | O=C1C=C2CCC3C(CCC4(C)C(C(=O)C)CCC34)C2(C)CC1 |
| Substrate Structure |
Product Information:
| Product Name | 11alpha-Hydroxyprogesterone |
| Product Chemical Formula | C21H30O3 |
| Product PubChem CID | 92730 |
| Product CAS Number | 80-75-1 |
| Product Smiles | O=C1C=C2CCC3C4CCC(C(=O)C)C4(C)CC(O)C3C2(C)CC1 |
| Product Structure |
| Product Name | 15beta-Hydroxyprogesterone |
| Product Chemical Formula | C21H30O3 |
| Product PubChem CID | 23239834 |
| Product CAS Number | 600-72-6 |
| Product Smiles | O=C1C=C2CCC3C(CCC4(C)C(C(=O)C)CC(O)C34)C2(C)CC1 |
| Product Structure |
| Product Name | 6beta-Hydroxyprogesterone |
| Product Chemical Formula | C21H30O3 |
| Product PubChem CID | 200149 |
| Product CAS Number | 604-19-3 |
| Product Smiles | O=C1C=C2C(O)CC3C(CCC4(C)C(C(=O)C)CCC34)C2(C)CC1 |
| Product Structure |
References:
| Title: | Towards preparative scale steroid hydroxylation with cytochrome P450 monooxygenase CYP106A2. |
| PMID: | 20183841 |
| Journal: | ChemBioChem |
| Year: | 2010/3/17 |