Detail Information
P450 Protein:
| P450 Symbol | aziB1 |
| Protein Name | 5-methyl-1-naphthoate 3-hydroxylase |
| Uniprot ID | B4XY99 |
| EC Number | 1.14.13.189 |
| Species | Streptomyces sahachiroi |
| Txid | 285525 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C12H10O2 → C12H10O3 |
| Reaction Type | Oxidation |
| Chemical Bond | C=O |
| Solvents | Water |
| Conditions | 30 min, pH 4.5-5.5, 25°C |
| Transformations | 1.Hydroxylation of Aromatic Compounds 2.Hydroxylation at an Aromatic Carbon |
aziB1
Substrate Information:
| Substrate Name | 5-Methyl-1-naphthoic acid |
| Substrate Chemical Formula | C12H10O2 |
| Substrate PubChem CID | 13454957 |
| Substrate Smiles | O=C(O)C1=CC=CC=2C1=CC=CC2C |
| Substrate Structure |
Product Information:
| Product Name | 3-Hydroxy-5-methyl-1-naphthalenecarboxylic acid |
| Product Chemical Formula | C12H10O3 |
| Product PubChem CID | 85787655 |
| Product CAS Number | 34581-87-8 |
| Product Smiles | O=C(O)C=1C=C(O)C=C2C1C=CC=C2C |
| Product Structure |
References:
| Title: | Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B. |
| PMID: | 20485749 |
| Journal: | Molecular BioSystems |
| Year: | 2010/3/16 |