Detail Information
P450 Protein:
| P450 Symbol | AurH |
| Protein Name | Putative cytochrome P450 |
| Uniprot ID | Q70KH6 |
| EC Number | 1.14.15.37 |
| Gene ID | 66737957 |
| Species | Streptomyces thioluteus |
| Txid | 66431 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C22H25BrO3 → C22H23BrO4 |
| Reaction Type | Oxidation |
| Chemical Bond | CH3 |
| Solvents | Dimethyl sulfoxide, Water |
| Conditions | 5 d, pH 7.4, 30°C |
AurH
Substrate Information:
| Substrate Name | 2-[(3E,5E)-6-(4-Bromophenyl)-3,5-dimethyl-3,5-hexadien-1-yl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one |
| Substrate Chemical Formula | C22H25BrO3 |
| Substrate PubChem CID | 46898045 |
| Substrate Smiles | O=C1C(=C(OC(=C1C)CCC(=CC(=CC2=CC=C(Br)C=C2)C)C)OC)C |
| Substrate Structure |
Product Information:
| Product Name | 2-[(2R,4Z)-4-[(2E)-3-(4-Bromophenyl)-2-methyl-2-propen-1-ylidene]tetrahydro-2-furanyl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one |
| Product Chemical Formula | C22H23BrO4 |
| Product PubChem CID | 44250990 |
| Product CAS Number | 1190898-79-3 |
| Product Smiles | O=C1C(=C(OC(=C1C)C2OCC(=CC(=CC3=CC=C(Br)C=C3)C)C2)OC)C |
| Product Structure |
References:
| Title: | Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. |
| PMID: | 20662518 |
| Journal: | Journal of the American Chemical Society |
| Year: | 2010/6/13 |