Detail Information
P450 Protein:
| P450 Symbol | AurH |
| Protein Name | Putative cytochrome P450 |
| Uniprot ID | Q70KH6 |
| EC Number | 1.14.15.37 |
| Gene ID | 66737957 |
| Species | Streptomyces thioluteus |
| Txid | 66431 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C22H25NO5 → C22H25NO6 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
| Solvents | Dimethyl sulfoxide, Water |
| Conditions | 5 d, pH 7.4, 30°C |
| Transformations | Hydroxylation at Aliphatic Carbon |
AurH
Substrate Information:
| Substrate Name | 2-[(3E,5E)-3,5-Dimethyl-6-(4-nitrophenyl)-3,5-hexadien-1-yl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one |
| Substrate Chemical Formula | C22H25NO5 |
| Substrate PubChem CID | 11246062 |
| Substrate Smiles | O=C1C(=C(OC(=C1C)CCC(=CC(=CC2=CC=C(C=C2)N(=O)=O)C)C)OC)C |
| Substrate Structure |
Product Information:
| Product Name | 2-[(1R,3E,5E)-1-Hydroxy-3,5-dimethyl-6-(4-nitrophenyl)-3,5-hexadien-1-yl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one |
| Product Chemical Formula | C22H25NO6 |
| Product PubChem CID | 102027521 |
| Product CAS Number | 1101168-58-4 |
| Product Smiles | O=C1C(=C(OC(=C1C)C(O)CC(=CC(=CC2=CC=C(C=C2)N(=O)=O)C)C)OC)C |
| Product Structure |
References:
| Title: | Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. |
| PMID: | 20662518 |
| Journal: | Journal of the American Chemical Society |
| Year: | 2010/6/13 |