Detail Information
P450 Protein:
| P450 Symbol | CYP153A13a |
| Protein Name | |
| Uniprot ID | |
| Species | A. borkumensis SK2 |
| Txid | 393595 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C8H8O2 → C8H8O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Dimethyl sulfoxide Water |
| Conditions | 24 h, 28°C |
| Transformations | 1.Hydroxylation of Aromatic Compounds 2.Hydroxylation at an Aromatic Carbon |
CYP153A13a
Substrate Information:
| Substrate Name | 2-Hydroxyacetophenone |
| Substrate Chemical Formula | C8H8O2 |
| Substrate PubChem CID | 8375 |
| Substrate Smiles | O=C(C=1C=CC=CC1O)C |
| Substrate Structure |
Product Information:
| Product Name | 2′,5′-Dihydroxyacetophenone |
| Product Chemical Formula | C8H8O3 |
| Product PubChem CID | 10279 |
| Product CAS Number | 490-78-8 |
| Product Smiles | O=C(C1=CC(O)=CC=C1O)C |
| Product Structure |
References:
| Title: | Bioconversion of aromatic compounds by Escherichia coli that expresses cytochrome P450 CYP153A13a gene isolated from an alkane-assimilating marine bacterium Alcanivorax borkumensis |
| DOI: | https://doi.org/10.1016/j.molcatb.2010.05.015 |
| Journal: | Journal of Molecular Catalysis B: Enzymatic |
| Year: | 2010/9/ |