Detail Information

P450 Protein:

P450 Symbol
Protein NameP450Um-1
Uniprot IDQ59HJ0
SpeciesAmycolatopsis azurea
Txid 36819
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C29H42N4O6 → C29H42N4O7
Reaction TypeOxidation
Chemical BondCH
SolventsWater
Conditions12 h, 30°C
Transformations1.Hydroxylation of Aromatic Compounds 2.Hydroxylation at an Aromatic Carbon

p-Deoxy-AS 1429716

Cyclo[(2S,9R)-2-amino-9-hydroxy-8-oxodecanoyl-L-isovalyl-L-tyrosyl-D-prolyl]

Substrate Information:

Substrate Name p-Deoxy-AS 1429716
Substrate Chemical FormulaC29H42N4O6
Substrate PubChem CID44563351
Substrate SmilesO=C1N2[C@@](C(=O)N[C@@H](CCCCCC([C@@H](C)O)=O)C(=O)N[C@](CC)(C)C(=O)N[C@H]1CC3=CC=CC=C3)(CCC2)[H]
Substrate Structure

Product Information:

Product Name Cyclo[(2S,9R)-2-amino-9-hydroxy-8-oxodecanoyl-L-isovalyl-L-tyrosyl-D-prolyl]
Product Chemical FormulaC29H42N4O7
Product PubChem CID49871644
Product CAS Number561042-39-5
Product SmilesO=C1N2[C@@](C(=O)N[C@@H](CCCCCC([C@@H](C)O)=O)C(=O)N[C@](CC)(C)C(=O)N[C@H]1CC3=CC=C(O)C=C3)(CCC2)[H]
Product Structure

References:

Title: Cloning and heterologous expression of P450Um-1, a novel bacterial P450 gene, for hydroxylation of immunosuppressive agent AS1387392.
PMID: 20924385
Journal: Journal of Antibiotics
Year: 2010/10/6

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics