Detail Information
P450 Protein:
| P450 Symbol | CYP154 |
| Protein Name | |
| Uniprot ID | |
| Species | Nocardia farcinica (strain IFM 10152) |
| Txid | 247156 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C16H12O4 → C15H10O4 |
| Reaction Type | Oxidation |
| Chemical Bond | OCH3 |
| Solvents | Water |
| Conditions | 24 h, pH 7, 37°C |
CYP154
Substrate Information:
| Substrate Name | Formononetin |
| Substrate Chemical Formula | C16H12O4 |
| Substrate PubChem CID | 5280378 |
| Substrate Smiles | O=C1C(=COC2=CC(O)=CC=C21)C=3C=CC(OC)=CC3 |
| Substrate Structure |
Product Information:
| Product Name | Daidzein |
| Product Chemical Formula | C15H10O4 |
| Product PubChem CID | 5281708 |
| Product CAS Number | 486-66-8 |
| Product Smiles | O=C1C(=COC2=CC(O)=CC=C12)C=3C=CC(O)=CC3 |
| Product Structure |
References:
| Title: | Characterization of bi-functional CYP154 from Nocardia farcinica IFM10152 in the O-dealkylation and ortho-hydroxylation of formononetin |
| DOI: | https://doi.org/10.1016/j.enzmictec.2010.08.006 |
| Journal: | Enzyme and Microbial Technology |
| Year: | 2010/11/8 |