Detail Information
P450 Protein:
| P450 Symbol | CYP199A4 |
| Protein Name | CYP199A4 F185I |
| Uniprot ID | |
| Species | Rhodopseudomonas palustris HaA2 |
| Txid | 316058 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
| Remarks | Mutations versus WT: F185I |
Reaction Scheme:
| Chemical Conversion | C9H10O2 → C9H8O2 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP199A4
Substrate Information:
| Substrate Name | 4-Ethylbenzoic Acid |
| Substrate Chemical Formula | C9H10O2 |
| Substrate PubChem CID | 12086 |
| Substrate Smiles | CCC1=CC=C(C=C1)C(=O)O |
| Substrate Structure |
Product Information:
| Product Name | 4-Vinylbenzoic acid |
| Product Chemical Formula | C9H8O2 |
| Product PubChem CID | 14098 |
| Product Smiles | C=CC1=CC=C(C=C1)C(=O)O |
| Product Structure |
References:
| Title: | Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering. |
| PMID: | 23135838 |
| Journal: | Chemistry - A European Journal |
| Year: | 2012/11/7 |