Detail Information
P450 Protein:
| P450 Symbol | CYP199A4 |
| Protein Name | Cytochrome P450 199A4 |
| Uniprot ID | Q2IU02 |
| EC Number | 1.14.99.15 |
| Species | Rhodopseudomonas palustris HaA2 |
| Txid | 316058 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C10H12O2 → C10H12O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP199A4
Substrate Information:
| Substrate Name | Cumic acid |
| Substrate Chemical Formula | C10H12O2 |
| Substrate PubChem CID | 10820 |
| Substrate Smiles | CC(C)C1=CC=C(C=C1)C(=O)O |
| Substrate Structure |
Product Information:
| Product Name | 4-(2-Hydroxypropan-2-yl)benzoic acid |
| Product Chemical Formula | C10H12O3 |
| Product PubChem CID | 226122 |
| Product CAS Number | 3609-50-5 |
| Product Smiles | CC(C)(C1=CC=C(C=C1)C(=O)O)O |
| Product Structure |
References:
| Title: | Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering. |
| PMID: | 23135838 |
| Journal: | Chemistry - A European Journal |
| Year: | 2012/11/7 |