Detail Information
P450 Protein:
| P450 Symbol | CYP105A1 |
| Protein Name | Vitamin D3 dihydroxylase |
| Uniprot ID | P18326 |
| EC Number | 1.14.15.22 |
| Species | Streptomyces griseolus |
| Txid | 1909 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H28O2 → C20H28O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Ethanol,Water |
| Conditions | 30 min, pH 7.4, 30°C |
| Transformations | Hydroxylation at an Aliphatic Carbon |
CYP105A1
Substrate Information:
| Substrate Name | Dehydroabietic acid |
| Substrate Chemical Formula | C20H28O2 |
| Substrate PubChem CID | 94391 |
| Substrate Smiles | C[C@@]12[C@]([C@@](C(O)=O)(C)CCC1)(CCC=3C2=CC=C(C(C)C)C3)[H] |
| Substrate Structure |
Product Information:
| Product Name | 15-Hydroxydehydroabietic acid |
| Product Chemical Formula | C20H28O3 |
| Product PubChem CID | 14487943 |
| Product CAS Number | 54113-95-0 |
| Product Smiles | C[C@@]12[C@]([C@@](C(O)=O)(C)CCC1)(CCC=3C2=CC=C(C(C)(C)O)C3)[H] |
| Product Structure |
References:
| Title: | Resin acid conversion with CYP105A1: an enzyme with potential for the production of pharmaceutically relevant diterpenoids. |
| PMID: | 23371760 |
| Journal: | ChemBioChem |
| Year: | 2013/2/1 |