Detail Information
P450 Protein:
| P450 Symbol | P450RhF |
| Protein Name | Cytochrome P450 RhF |
| Uniprot ID | Q8KU27 |
| Species | Rhodococcus sp. NCIMB 9784 |
| Txid | 157732 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C8H7NS → C8H7NOS |
| Reaction Type | Oxidation |
| Chemical Bond | S-CH3 |
| Solvents | Dimethyl sulfoxide,Water |
| Conditions | 48 h, pH 7.8, 20°C |
| Transformations | Oxidation of Thioethers to Sulfoxides and Sulfones |
P450RhF
Substrate Information:
| Substrate Name | 4-(Methylthio)benzonitrile |
| Substrate Chemical Formula | C8H7NS |
| Substrate PubChem CID | 590960 |
| Substrate Smiles | N#CC1=CC=C(SC)C=C1 |
| Substrate Structure |
Product Information:
| Product Name | 4-[(S)-Methylsulfinyl]benzonitrile |
| Product Chemical Formula | C8H7NOS |
| Product PubChem CID | 11116407 |
| Product CAS Number | 60958-04-5 |
| Product Smiles | S(C)(=O)C1=CC=C(C#N)C=C1 |
| Product Structure |
References:
| Title: | Substrate promiscuity of cytochrome P450 RhF |
| DOI: | https://doi.org/10.1039/C3CY00091E |
| Journal: | Catalysis Science & Technology |
| Year: | 2013/4/3 |