Detail Information

P450 Protein:

P450 SymbolCYP105A1
Protein NameVitamin D3 dihydroxylase
Uniprot IDP18326
EC Number1.14.15.22
SpeciesStreptomyces griseolus
Txid 1909
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C20H30O2 → C20H30O3
Reaction TypeOxidation
Chemical BondC=C
SolventsEthanol,Water
Conditions30 min, pH 7.4, 30°C

Isopimaric acid

CYP105A1

(1R,4aR,4bS,7S,10aR)-1,2,3,4,4a,4b,5,6,7,8,10,10a-Dodecahydro-1,4a,7-trimethyl-7-(2S)-2-oxiranyl-1-phenanthrenecarboxylic acid

Substrate Information:

Substrate Name Isopimaric acid
Substrate Chemical FormulaC20H30O2
Substrate PubChem CID442048
Substrate SmilesC[C@@]12[C@]([C@@](C(O)=O)(C)CCC1)(CC=C3[C@@]2(CC[C@@](C=C)(C)C3)[H])[H]
Substrate Structure

Product Information:

Product Name (1R,4aR,4bS,7S,10aR)-1,2,3,4,4a,4b,5,6,7,8,10,10a-Dodecahydro-1,4a,7-trimethyl-7-(2S)-2-oxiranyl-1-phenanthrenecarboxylic acid
Product Chemical FormulaC20H30O3
Product CAS Number1472645-91-2
Product SmilesC[C@@]12[C@@]3(C(C[C@](C)(CC3)[C@]4(CO4)[H])=CC[C@]1([C@@](C(O)=O)(C)CCC2)[H])[H]
Product Structure

References:

Title: Resin acid conversion with CYP105A1: an enzyme with potential for the production of pharmaceutically relevant diterpenoids.
PMID: 23371760
Journal: ChemBioChem
Year: 2013/2/1

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
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