Detail Information
P450 Protein:
| P450 Symbol | rauA |
| Protein Name | Cytochrome P450 |
| Uniprot ID | S6BVH1 |
| Species | Rhodococcus erythropolis JCM 6824 |
| Txid | 1833 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C25H33NO2 → C25H33NO3 |
| Reaction Type | Oxidation |
| Chemical Bond | NH |
| Solvents | Water |
| Conditions | 2 - 5 min, pH 7.5, 30°C |
| Transformations | Oxidation of Amines to Nitroso Compounds, Hydroxylamines and Related |
rauA
Substrate Information:
| Substrate Name | 3-[(2E,6E)-9-Hydroxy-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-2-methyl-4(1H)-quinolinone |
| Substrate Chemical Formula | C25H33NO2 |
| Substrate Smiles | O=C1C=2C(NC(C)=C1C/C=C(/CC/C=C(/CC(C=C(C)C)O)C)C)=CC=CC2 |
| Substrate Structure |
Product Information:
| Product Name | 1-Hydroxy-3-[(2E,6E)-9-hydroxy-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-2-methyl-4(1H)-quinolinone |
| Product Chemical Formula | C25H33NO3 |
| Product CAS Number | 1208334-78-4 |
| Product Smiles | O=C1C=2C(N(O)C(C)=C1C/C=C(/CC/C=C(/CC(C=C(C)C)O)C)C)=CC=CC2 |
| Product Structure |
References:
| Title: | Structure of the quinoline N-hydroxylating cytochrome P450 RauA, an essential enzyme that confers antibiotic activity on aurachin alkaloids. |
| PMID: | 24269679 |
| Journal: | FEBS Letters |
| Year: | 2013/11/20 |