Detail Information
P450 Protein:
| P450 Symbol | CYP106A1 |
| Protein Name | Cytochrome P450 |
| Uniprot ID | D5DF35 |
| Species | Bacillus megaterium DSM319 |
| Txid | 592022 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C30H46O4 → C30H46O6 + C30H46O5 + C30H46O5 |
| Reaction Type | Intramolecular diazo-mediated nucleophilic cyclization-elimination |
| Chemical Bond | CH |
| Solvents | Water |
| Conditions | 100 min, pH 7.4, 30°C |
| Transformations | Hydroxylation at an Aliphatic Carbon |
CYP106A1
+
+
Substrate Information:
| Substrate Name | 11-Keto-beta-boswellic acid |
| Substrate Chemical Formula | C30H46O4 |
| Substrate PubChem CID | 9847548 |
| Substrate Smiles | C[C@]12[C@@]([C@]3(C)[C@@](CC1)([C@](C(O)=O)(C)[C@H](O)CC3)[H])(C(=O)C=C4[C@@]2(C)CC[C@]5(C)[C@]4([C@@H](C)[C@H](C)CC5)[H])[H] |
| Substrate Structure |
Product Information:
| Product Name | (3alpha,4beta,7beta,15alpha)-3,7,15-Trihydroxy-11-oxours-12-en-23-oic acid |
| Product Chemical Formula | C30H46O6 |
| Product CAS Number | 1492065-18-5 |
| Product Smiles | C[C@]12[C@@]3(C)[C@@]([C@]4(C)[C@@](C[C@@H]3O)([C@](C(O)=O)(C)[C@H](O)CC4)[H])(C(=O)C=C1[C@]5([C@@](C)(C[C@@H]2O)CC[C@@H](C)[C@@H]5C)[H])[H] |
| Product Structure |
| Product Name | (3alpha,4beta,7beta)-3,7-Dihydroxy-11-oxours-12-en-23-oic acid |
| Product Chemical Formula | C30H46O5 |
| Product CAS Number | 1492065-14-1 |
| Product Smiles | C[C@]12[C@@]([C@]3(C)[C@@](C[C@@H]1O)([C@](C(O)=O)(C)[C@H](O)CC3)[H])(C(=O)C=C4[C@@]2(C)CC[C@]5(C)[C@]4([C@@H](C)[C@H](C)CC5)[H])[H] |
| Product Structure |
| Product Name | (3alpha,4beta,15alpha)-3,15-Dihydroxy-11-oxours-12-en-23-oic acid |
| Product Chemical Formula | C30H46O5 |
| Product CAS Number | 1385015-73-5 |
| Product Smiles | C[C@]12[C@@]3(C)[C@@]([C@]4(C)[C@@](CC3)([C@](C(O)=O)(C)[C@H](O)CC4)[H])(C(=O)C=C1[C@]5([C@@](C)(C[C@@H]2O)CC[C@@H](C)[C@@H]5C)[H])[H] |
| Product Structure |
References:
| Title: | A new cytochrome P450 system from Bacillus megaterium DSM319 for the hydroxylation of 11-keto-β-boswellic acid (KBA). |
| PMID: | 23797329 |
| Journal: | Applied Microbiology and Biotechnology |
| Year: | 2013/6/25 |