Detail Information
P450 Protein:
| P450 Symbol | af510 |
| Protein Name | Multifunctional cytochrome P450 monooxygenase af510 |
| Uniprot ID | Q4WAZ6 |
| Species | Aspergillus fumigatus |
| Txid | 330879 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C15H24 → C15H24O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Water |
| Conditions | 14 h, pH 7.4, 30°C |
| Transformations | Epoxidation of Alkenes |
af510
Substrate Information:
| Substrate Name | trans-beta-Bergamotene |
| Substrate Chemical Formula | C15H24 |
| Substrate PubChem CID | 12300069 |
| Substrate Smiles | C(CC=C(C)C)[C@@]1(C)[C@]2(C[C@@]1(CCC2=C)[H])[H] |
| Substrate Structure |
Product Information:
| Product Name | 6-epi-5-Demethoxyfumagillol |
| Product Chemical Formula | C15H24O3 |
| Product CAS Number | 701277-78-3 |
| Product Smiles | C[C@@]1([C@@]2([C@@]3(CO3)CC[C@H](O)C2)[H])[C@@H](CC=C(C)C)O1 |
| Product Structure |
References:
| Title: | Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway. |
| PMID: | 24568283 |
| Journal: | Journal of the American Chemical Society |
| Year: | 2014/2/26 |