Detail Information

P450 Protein:

P450 Symbol	bezE
Protein Name	Cytochrome P450 monooxygenase
Uniprot ID	A0A2Z5X755
Species	Streptomyces sp. RI18
Txid	1894972
P450 Protein Structure	Go to AlphaFold Website Model Confidence (pLDDT) Very high (>90) High (90 > 70) Low (70 > 50) Very low (<50) Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence	GO

Reaction Scheme:

4-(acetoxyamino)-3-[(2Z)-3-(hydroxymethyl)-6,7-dimethylocta-2,6-dienyl]benzoic acid

bezE

(2R,3R)-3-chloro-2-(3,4-dimethylpent-3-enyl)-2-(hydroxymethyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid

Substrate Information:

Substrate Name	4-(acetoxyamino)-3-[(2Z)-3-(hydroxymethyl)-6,7-dimethylocta-2,6-dienyl]benzoic acid
Substrate Chemical Formula	C20H27NO5
Substrate Smiles	O=C(C)ONC1=C(C=C(C=C1)C(O)=O)C/C=C(CO)/CC/C(=C(C)/C)/C
Substrate Structure	Download SDF

Product Information:

Product Name	(2R,3R)-3-chloro-2-(3,4-dimethylpent-3-enyl)-2-(hydroxymethyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid
Product Chemical Formula	C18H24ClNO3
Product Smiles	OC(C1=CC=C2C(=C1)C[C@@H](Cl)[C@](CO)(CC/C(/C)=C(C)/C)N2)=O
Product Structure	Download SDF

References:

Title:	Unprecedented Cyclization Catalyzed by a Cytochrome P450 in Benzastatin Biosynthesis.
PMID:	29716187
Journal:	Journal of the American Chemical Society
Year:	2018/5/2