Detail Information

P450 Protein:

P450 SymbolbezE
Protein NameCytochrome P450 monooxygenase
Uniprot IDA0A2Z5X755
SpeciesStreptomyces sp. RI18
Txid 1894972
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C21H29NO4 → C18H25NO3
Reaction TypeCyclization
Chemical BondC=C

4-(acetoxyamino)-3-[(2E)-3-ethyl-6,7-dimethylocta-2,6-dienyl]benzoic acid

bezE

(2S)-2-[(2R)-2-hydroxy-5,6-dimethylhept-5-en-2-yl]-2,3-dihydro-1H-indole-5-carboxylic acid

Substrate Information:

Substrate Name 4-(acetoxyamino)-3-[(2E)-3-ethyl-6,7-dimethylocta-2,6-dienyl]benzoic acid
Substrate Chemical FormulaC21H29NO4
Substrate SmilesO=C(ONC1C=CC(C(=O)O)=CC=1C/C=C(/CC/C(/C)=C(C)/C)CC)C
Substrate Structure

Product Information:

Product Name (2S)-2-[(2R)-2-hydroxy-5,6-dimethylhept-5-en-2-yl]-2,3-dihydro-1H-indole-5-carboxylic acid
Product Chemical FormulaC18H25NO3
Product PubChem CID156582192
Product CAS Number2230052-85-2
Product SmilesCC(=C(C)CC[C@](C)([C@@H]1CC2=C(N1)C=CC(=C2)C(=O)O)O)C
Product Structure

References:

Title: Unprecedented Cyclization Catalyzed by a Cytochrome P450 in Benzastatin Biosynthesis.
PMID: 29716187
Journal: Journal of the American Chemical Society
Year: 2018/5/2

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics