Detail Information
P450 Protein:
| P450 Symbol | P450PL2-4 |
| Protein Name | Cytochrome P450 |
| Uniprot ID | A7HP72 |
| Species | Parvibaculum lavamentivorans |
| Txid | 402881 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C9H11Br → C9H11BrO |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Water |
| Conditions | 12 h, pH 8.5, 35°C |
| Transformations | Hydroxylation at an Aliphatic Carbon |
P450PL2-4
Substrate Information:
| Substrate Name | 1-(2-bromoethyl)-3-methylbenzene |
| Substrate Chemical Formula | C9H11Br |
| Substrate PubChem CID | 570684 |
| Substrate Smiles | CC1=CC(=CC=C1)CCBr |
| Substrate Structure |
Product Information:
| Product Name | (alphaR)-alpha-(Bromomethyl)-3-methylbenzenemethanol |
| Product Chemical Formula | C9H11BrO |
| Product CAS Number | 2366199-79-1 |
| Product Smiles | [C@@H](CBr)(O)C1=CC(C)=CC=C1 |
| Product Structure |
References:
| Title: | Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons |
| DOI: | https://doi.org/10.1039/C9GC01802F |
| Journal: | Green Chemistry |
| Year: | 2019/7/17 |