Detail Information

P450 Protein:

P450 Symbol	ttmP
Protein Name	TtmP
Uniprot ID	A0A0P0FVK8
Species	Streptomyces afghaniensis
Txid	66865
P450 Protein Structure	Go to AlphaFold Website Model Confidence (pLDDT) Very high (>90) High (90 > 70) Low (70 > 50) Very low (<50) Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence	GO

Reaction Scheme:

(5R)-3,5-diethyl-4-hydroxy-5-[(1E)-2-methylbuta-1,3-dienyl]-2,5-dihydrothiophen-2-one

ttmP

[(2R)-4-ethyl-3-hydroxy-2-[(1E)-2-methylbuta-1,3-dienyl]-5-oxo-2,5-dihydrothiophen-2-yl]acetic acid

Substrate Information:

Substrate Name	(5R)-3,5-diethyl-4-hydroxy-5-[(1E)-2-methylbuta-1,3-dienyl]-2,5-dihydrothiophen-2-one
Substrate Chemical Formula	C13H18O2S
Substrate PubChem CID	135754258
Substrate Smiles	O=C1C(CC)=C([C@@](CC)(/C=C(/C=C)C)S1)O
Substrate Structure	Download SDF

Product Information:

Product Name	[(2R)-4-ethyl-3-hydroxy-2-[(1E)-2-methylbuta-1,3-dienyl]-5-oxo-2,5-dihydrothiophen-2-yl]acetic acid
Product Chemical Formula	C13H16O4S
Product Smiles	O=C(C[C@]1(C(=C(CC)C(=O)S1)O)/C=C(C)/C=C)O
Product Structure	Download SDF

References:

Title:	Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives.
PMID:	30869693
Journal:	Organic & Biomolecular Chemistry
Year:	2019/3/11