Detail Information
P450 Protein:
| P450 Symbol | CYP101A1 |
| Protein Name | Camphor 5-monooxygenase |
| Uniprot ID | P00183 |
| EC Number | 1.14.15.1 |
| Gene ID | 9617760 |
| Species | Pseudomonas putida |
| Txid | 303 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C10H16S → C10H16OS + C10H16OS + C10H16OS |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP101A1
+
+
Substrate Information:
| Substrate Name | Thiocamphor |
| Substrate Chemical Formula | C10H16S |
| Substrate PubChem CID | 5446 |
| Substrate Smiles | CC1(C2CCC1(C(=S)C2)C)C |
| Substrate Structure |
Product Information:
| Product Name | 3-hydroxy-1,7,7-trimethylbicyclo[2.2.1]heptane-6-thione |
| Product Chemical Formula | C10H16OS |
| Product Smiles | [H]C1(C2C(C)(C)C(C1)(C)C(C2)=S)O |
| Product Structure |
| Product Name | 6-hydroxy-1,7,7-trimethylbicyclo[2.2.1]heptane-2-thione |
| Product Chemical Formula | C10H16OS |
| Product Smiles | [H]C1(C(C)2C(CC(C2(C)C)C1)=S)O |
| Product Structure |
| Product Name | 3-hydroxy-1,7,7-trimethylbicyclo[2.2.1]heptane-2-thione |
| Product Chemical Formula | C10H16OS |
| Product PubChem CID | 129846760 |
| Product Smiles | CC1(C2CCC1(C(=S)C2O)C)C |
| Product Structure |
References:
| Title: | The roles of active site hydrogen bonding in cytochrome P-450cam as revealed by site-directed mutagenesis. |
| PMID: | 3198602 |
| Journal: | J Biol Chem |
| Year: | 1988/12/15 |