Detail Information

P450 Protein:

P450 SymbolCYP176A1
Protein Name1,8-cineole 2-endo-monooxygenase
Uniprot IDQ8VQF6
EC Number1.14.14.133
SpeciesCitrobacter braakii
Txid 57706
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C10H18 → C10H18O + C10H18O
Reaction TypeOxidation
Chemical BondCH

Bornane

CYP176A1

4,7,7-trimethylbicyclo[2.2.1]heptan-2-ol

+

1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol

Substrate Information:

Substrate Name Bornane
Substrate Chemical FormulaC10H18
Substrate PubChem CID92108
Substrate SmilesCC1(C2CCC1(CC2)C)C
Substrate Structure

Product Information:

Product Name 4,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
Product Chemical FormulaC10H18O
Product PubChem CID565679
Product CAS Number22336-76-1
Product SmilesCC1(C2CCC1(CC2O)C)C
Product Structure
Product Name 1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
Product Chemical FormulaC10H18O
Product PubChem CID64685
Product CAS Number507-70-0
Product SmilesCC1(C2CCC1(C(C2)O)C)C
Product Structure

References:

Title: Oxygen activation by P450(cin): Protein and substrate mutagenesis.
PMID: 20851096
Journal: Arch Biochem Biophys
Year: 2011/3/1

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
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