Detail Information
P450 Protein:
| P450 Symbol | HbcI |
| Protein Name | Cytochrome P450 monooxygenase |
| Uniprot ID | A0A7S5UBC9 |
| Species | Streptomyces sp. |
| Txid | 1931 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C22H27N5O10 → C22H27N5O11 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Water |
| Transformations | Hydroxylation at an Aliphatic Carbon |
HbcI
Substrate Information:
| Substrate Name | methyl (1R,3R,4R,5R,7R,9R,11S,12S,13S)-5-(6-aminopurin-9-yl)-1,4,12-trihydroxy-13-[(E)-2-methylbut-2-enoyl]oxy-2,6,10-trioxatricyclo[7.4.0.03,7]tridecane-11-carboxylate |
| Substrate Chemical Formula | C22H27N5O10 |
| Substrate PubChem CID | 76317500 |
| Substrate Smiles | C/C=C(C)/C(=O)O[C@H]1[C@@H]([C@H](O[C@H]2[C@]1(O[C@H]3[C@@H](C2)O[C@H]([C@@H]3O)N4C=NC5=C(N=CN=C54)N)O)C(=O)OC)O |
| Substrate Structure |
Product Information:
| Product Name | methyl (1R,3R,4R,5R,7R,9R,11S,12S,13S)-5-(6-aminopurin-9-yl)-1,4,12-trihydroxy-13-[(E)-2-(hydroxymethyl)but-2-enoyl]oxy-2,6,10-trioxatricyclo[7.4.0.03,7]tridecane-11-carboxylate |
| Product Chemical Formula | C22H27N5O11 |
| Product PubChem CID | 168447663 |
| Product CAS Number | 2342577-63-1 |
| Product Smiles | C/C=C(CO)/C(=O)O[C@H]1[C@@H]([C@H](O[C@H]2[C@]1(O[C@H]3[C@@H](C2)O[C@H]([C@@H]3O)N4C=NC5=C(N=CN=C54)N)O)C(=O)OC)O |
| Product Structure |
References:
| Title: | Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity. |
| PMID: | 30763106 |
| Journal: | Organic Letters |
| Year: | 2019/2/14 |