Detail Information
P450 Protein:
| P450 Symbol | PtmO5 |
| Protein Name | PtmO5 |
| Uniprot ID | D8L2V0 |
| Species | Streptomyces platensis |
| Txid | 58346 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H30O3 → C20H30O4 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Ethanol;Dimethyl sulfoxide |
| Conditions | 20 h, 23°C |
| Transformations | Hydroxylation at an Aliphatic Carbon |
PtmO5
Substrate Information:
| Substrate Name | (1R,4S,5R,9S,10R,13S)-5,9,13-trimethyl-14-oxotetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid |
| Substrate Chemical Formula | C20H30O3 |
| Substrate PubChem CID | 99514 |
| Substrate Smiles | C[C@]12CC[C@H]3[C@@]4(CCC[C@@]([C@H]4CC[C@@]3(C1)CC2=O)(C)C(=O)O)C |
| Substrate Structure |
Product Information:
| Product Name | (1R,4S,5R,9S,10R,12R,13R)-12-hydroxy-5,9,13-trimethyl-14-oxotetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid |
| Product Chemical Formula | C20H30O4 |
| Product PubChem CID | 44566716 |
| Product CAS Number | 181712-01-6 |
| Product Smiles | C[C@@]12CCC[C@@]([C@H]1CC[C@@]34[C@H]2C[C@H]([C@@](C3)(C(=O)C4)C)O)(C)C(=O)O |
| Product Structure |
References:
| Title: | Divergent synthesis of complex diterpenes through a hybrid oxidative approach. |
| PMID: | 32792393 |
| Journal: | Science (Washington, DC, United States) |
| Year: | 2020/8/14 |