Detail Information
P450 Protein:
| P450 Symbol | PtmO5 |
| Protein Name | PtmO5 |
| Uniprot ID | D8L2V0 |
| Species | Streptomyces platensis |
| Txid | 58346 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H28O4 → C20H28O5 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Ethanol;Dimethyl sulfoxide |
| Conditions | 20 h, 23°C |
| Transformations | Hydroxylation at an Aliphatic Carbon |
PtmO5
Substrate Information:
| Substrate Name | (1S,4S,5R,9S,10S,13S)-13-hydroxy-5,9-dimethyl-14-methylidene-2-oxotetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid |
| Substrate Chemical Formula | C20H28O4 |
| Substrate PubChem CID | 102272667 |
| Substrate Smiles | C[C@@]12CCC[C@@]([C@H]1CC(=O)[C@]34[C@H]2CC[C@](C3)(C(=C)C4)O)(C)C(=O)O |
| Substrate Structure |
Product Information:
| Product Name | (4alpha,11beta)-11,13-Dihydroxy-7-oxokaur-16-en-18-oic acid |
| Product Chemical Formula | C20H28O5 |
| Product CAS Number | 2488163-83-1 |
| Product Smiles | O=C1[C@]23[C@]([C@@]4(C)[C@](C1)([C@@](C(O)=O)(C)CCC4)[H])([C@@H](O)C[C@](O)(C2)C(=C)C3)[H] |
| Product Structure |
References:
| Title: | Divergent synthesis of complex diterpenes through a hybrid oxidative approach. |
| PMID: | 32792393 |
| Journal: | Science (Washington, DC, United States) |
| Year: | 2020/8/14 |