Detail Information
P450 Protein:
| P450 Symbol | DSH1 |
| Protein Name | Deoxyshikonin hydroxylase |
| Uniprot ID | A0A8A6LLE0 |
| Species | Arnebia euchroma |
| Txid | 373122 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C16H16O4 → C16H16O5 + C16H16O5 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Transformations | Hydroxylation at an Aliphatic Carbon |
DSH1
+
Substrate Information:
| Substrate Name | 5,8-Dihydroxy-2-(4-methyl-3-penten-1-yl)-1,4-naphthalenedione |
| Substrate Chemical Formula | C16H16O4 |
| Substrate Smiles | O=C1C=C(C(=O)C=2C(O)=CC=C(O)C12)CCC=C(C)C |
| Substrate Structure |
Product Information:
| Product Name | 5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione |
| Product Chemical Formula | C16H16O5 |
| Product CAS Number | 517-89-5 |
| Product Smiles | O=C1C=2C(C(=O)C=C1[C@@H](CC=C(C)C)O)=C(O)C=CC2O |
| Product Structure |
| Product Name | 5,8-Dihydroxy-2-[(1S)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione |
| Product Chemical Formula | C16H16O5 |
| Product CAS Number | 517-88-4 |
| Product Smiles | O=C1C=2C(C(=O)C=C1[C@H](CC=C(C)C)O)=C(O)C=CC2O |
| Product Structure |
References:
| Title: | CYP82AR Subfamily Proteins Catalyze C-1' Hydroxylations of Deoxyshikonin in the Biosynthesis of Shikonin and Alkannin. |
| PMID: | 33728922 |
| Journal: | Organic Letters |
| Year: | 2021/3/17 |