Detail Information

P450 Protein:

P450 SymbolDSH2
Protein NameDeoxyshikonin hydroxylase
Uniprot IDA0A8A6LE54
SpeciesArnebia euchroma
Txid 373122
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C16H16O4 → C16H16O5
Reaction TypeOxidation
Chemical BondCH
TransformationsHydroxylation at an Aliphatic Carbon

5,8-Dihydroxy-2-(4-methyl-3-penten-1-yl)-1,4-naphthalenedione

DSH2

5,8-Dihydroxy-2-[(1S)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione

Substrate Information:

Substrate Name 5,8-Dihydroxy-2-(4-methyl-3-penten-1-yl)-1,4-naphthalenedione
Substrate Chemical FormulaC16H16O4
Substrate SmilesO=C1C=C(C(=O)C=2C(O)=CC=C(O)C12)CCC=C(C)C
Substrate Structure

Product Information:

Product Name 5,8-Dihydroxy-2-[(1S)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione
Product Chemical FormulaC16H16O5
Product CAS Number517-88-4
Product SmilesO=C1C=2C(C(=O)C=C1[C@H](CC=C(C)C)O)=C(O)C=CC2O
Product Structure

References:

Title: CYP82AR Subfamily Proteins Catalyze C-1' Hydroxylations of Deoxyshikonin in the Biosynthesis of Shikonin and Alkannin.
PMID: 33728922
Journal: Organic Letters
Year: 2021/3/17

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics