Detail Information

P450 Protein:

P450 Symbol	RebP
Protein Name	RebP-like cytochrome P450
Uniprot ID	A0A8F5FCX1
Species	Streptomyces sp.
Txid	1931
P450 Protein Structure	Go to AlphaFold Website Model Confidence (pLDDT) Very high (>90) High (90 > 70) Low (70 > 50) Very low (<50) Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence	GO

Reaction Scheme:

Chemical Conversion	C11H11FN2O2 → C20H11F2N3O
Reaction Type	cyclization reaction
Chemical Bond
Solvents	Water
Conditions	20 h, pH 7.0, 25°C; 15 min, 85°C
Transformations	1.Transamination 2.Decarboxylation of Aliphatic Acids 3.Reduction of the C-N Bond/ Deamination

(2S)-2-amino-3-(4-fluoro-1H-indol-3-yl)propanoic acid

RebP

8,18-difluoro-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-12-one

Substrate Information:

Substrate Name	(2S)-2-amino-3-(4-fluoro-1H-indol-3-yl)propanoic acid
Substrate Chemical Formula	C11H11FN2O2
Substrate PubChem CID	688475
Substrate Smiles	C1=CC2=C(C(=C1)F)C(=CN2)C[C@@H](C(=O)O)N
Substrate Structure	Download SDF

Product Information:

Product Name	8,18-difluoro-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-12-one
Product Chemical Formula	C20H11F2N3O
Product PubChem CID	148641925
Product CAS Number	2305201-23-2
Product Smiles	C1C2=C3C4=C(C=CC=C4F)NC3=C5C(=C2C(=O)N1)C6=C(N5)C=CC=C6F
Product Structure	Download SDF

References:

Title:	一种星孢菌素中间体K252c及其衍生物的催化合成体系及催化合成方法
Patent ID:	CN112852899
Journal:
Year:	2021/5/28