Detail Information

P450 Protein:

P450 Symbol	RebP
Protein Name	RebP-like cytochrome P450
Uniprot ID	A0A8F5FCX1
Species	Streptomyces sp.
Txid	1931
P450 Protein Structure	Go to AlphaFold Website Model Confidence (pLDDT) Very high (>90) High (90 > 70) Low (70 > 50) Very low (<50) Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence	GO

Reaction Scheme:

Chemical Conversion	C12H14N2O3 → C22H17N3O3
Reaction Type	cyclization reaction
Chemical Bond
Solvents	Water
Conditions	20 h, pH 7.0, 25°C; 15 min, 85°C
Transformations	1.Transamination 2.Decarboxylation of Aliphatic Acids 3.Reduction of the C-N Bond/ Deamination

(2S)-2-amino-3-(5-methoxy-1H-indol-3-yl)propanoic acid

RebP

7,19-dimethoxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-12-one

Substrate Information:

Substrate Name	(2S)-2-amino-3-(5-methoxy-1H-indol-3-yl)propanoic acid
Substrate Chemical Formula	C12H14N2O3
Substrate PubChem CID	151018
Substrate Smiles	COC1=CC2=C(C=C1)NC=C2C[C@@H](C(=O)O)N
Substrate Structure	Download SDF

Product Information:

Product Name	7,19-dimethoxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-12-one
Product Chemical Formula	C22H17N3O3
Product PubChem CID	14699106
Product CAS Number	129514-15-4
Product Smiles	COC1=CC2=C(C=C1)NC3=C4C(=C5C(=C23)CNC5=O)C6=C(N4)C=CC(=C6)OC
Product Structure	Download SDF

References:

Title:	一种星孢菌素中间体K252c及其衍生物的催化合成体系及催化合成方法
Patent ID:	CN112852899
Journal:
Year:	2021/5/28