P450 Protein:

P450 Symbol	RebP
Protein Name	RebP-like cytochrome P450
Uniprot ID	A0A8F5FCX1
Species	Streptomyces sp.
Txid	1931
P450 Protein Structure	Go to AlphaFold Website Model Confidence (pLDDT) Very high (>90) High (90 > 70) Low (70 > 50) Very low (<50) Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence	GO

Reaction Scheme:

Chemical Conversion	C12H14N2O2 → C22H17N3O
Reaction Type	cyclization reaction
Chemical Bond
Solvents	Water
Conditions	20 h, pH 7.0, 25°C; 15 min, 85°C
Transformations	1.Transamination 2.Decarboxylation of Aliphatic Acids 3.Reduction of the C-N Bond/ Deamination

Substrate Information:

Substrate Name	(2S)-2-amino-3-(6-methyl-1H-indol-3-yl)propanoic acid
Substrate Chemical Formula	C12H14N2O2
Substrate PubChem CID	164910
Substrate Smiles	CC1=CC2=C(C=C1)C(=CN2)C[C@@H](C(=O)O)N
Substrate Structure	Download SDF

Product Information:

Product Name	2,10-dimethyl-6,7,12,13-tetrahydro-5H-pyrrolo[4,3-c]indolo[2,3-a]carbazol-5-one
Product Chemical Formula	C22H17N3O
Product CAS Number	2654831-45-3
Product Smiles	O=C1NCC2=C1C=3C=4C=CC(=CC4NC3C=5NC6=CC(=CC=C6C52)C)C
Product Structure	Download SDF

References: