Detail Information
P450 Protein:
| P450 Symbol | CYP110D1 |
| Protein Name | Cytochrome P450 |
| Uniprot ID | Q8YN07 |
| Species | Synechocystis sp. PCC 6803 |
| Txid | 1111708 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C19H28O2 → C19H28O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Dimethyl sulfoxide |
| Conditions | 8 h, rt |
| Transformations | Hydroxylation at an Aliphatic Carbon |
CYP110D1
Substrate Information:
| Substrate Name | (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| Substrate Chemical Formula | C19H28O2 |
| Substrate PubChem CID | 6013 |
| Substrate Smiles | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)CC[C@]34C |
| Substrate Structure |
Product Information:
| Product Name | (8R,9S,10R,13S,14S,15R,17S)-15,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| Product Chemical Formula | C19H28O3 |
| Product PubChem CID | 53255472 |
| Product CAS Number | 39605-73-7 |
| Product Smiles | C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3[C@@H](C[C@@H]4O)O)C |
| Product Structure |
References:
| Title: | Light-driven hydroxylation of testosterone by Synechocystis sp. PCC 6803 expressing the heterologous CYP450 monooxygenase CYP110D1 |
| DOI: | https://doi.org/10.1039/D1GC04714K |
| Journal: | Green Chemistry |
| Year: | 2022/7/6 |