Detail Information
P450 Protein:
| P450 Symbol | CYP1251 C3 |
| Protein Name | Cytochrome P450Blt |
| Uniprot ID | A0ACD6BAH8 |
| EC Number | 1.14.-.- |
| Species | Micromonospora sp. MW-13 |
| Txid | 2094022 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C37H49N11O7S → C37H47N11O7S |
| Reaction Type | Cyclization |
| Chemical Bond | |
| Solvents | Water |
| Conditions | overnight, 30°C |
CYP1251 C3
Substrate Information:
| Substrate Name | N-[(5S,8S,11S,14S)-14-(1H-indol-3-ylmethyl)-5-amino-8-(3-{[amino(azanylidene)methyl]amino}propyl)-11-[(4-hydroxyphenyl)methyl]-6,9,12,15-tetraoxo-2-thia-7,10,13-triazapentadec-15-yl]-L-histidine |
| Substrate Chemical Formula | C37H49N11O7S |
| Substrate Smiles | C([C@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@H](CCSC)N)=O)CCCNC(=N)N)=O)=O)C(N[C@@H](CC2=CN=CN2)C(O)=O)=O)C=3C=4C(NC3)=CC=CC4 |
| Substrate Structure |
Product Information:
| Product Name | (7S,10S,13S)-10-(1H-indol-3-ylmethyl)-13-{[(5S,8S)-5-amino-8-(3-{[amino(azanylidene)methyl]amino}propyl)-6,9-dioxo-7-aza-2-thianon-9-yl]amino}-18-hydroxy-9,12-dioxo-2,4,8,11-tetrazatricyclo[13.3.1.12,5]icosa-1(19),3,5(20),15(16),17-pentaene-7-carboxylic acid |
| Product Chemical Formula | C37H47N11O7S |
| Product CAS Number | 2951913-34-9 |
| Product Smiles | C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@@H](NC([C@@H](NC([C@H](CCSC)N)=O)CCCNC(=N)N)=O)CC4=CC(N5C=C(C[C@@H](C(O)=O)NC3=O)N=C5)=C(O)C=C4 |
| Product Structure |
References:
| Title: | Cytochrome P450(Blt) Enables Versatile Peptide Cyclisation to Generate Histidine- and Tyrosine-Containing Crosslinked Tripeptide Building Blocks. |
| PMID: | 35851739 |
| Journal: | Angewandte Chemie, International Edition |
| Year: | 2022/7/18 |