Detail Information
P450 Protein:
| P450 Symbol | CYP8B1 |
| Protein Name | Cytochrome P450 family 8 subfamily B member 1 |
| Uniprot ID | C9JFR9 |
| Species | Homo sapiens |
| Txid | 9606 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C27H44O2 → C27H44O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Transformations | Hydroxylation at an Aliphatic Carbon |
CYP8B1
Substrate Information:
| Substrate Name | (7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| Substrate Chemical Formula | C27H44O2 |
| Substrate PubChem CID | 123743 |
| Substrate Smiles | C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](CC4=CC(=O)CC[C@]34C)O)C |
| Substrate Structure |
Product Information:
| Product Name | (7R,8R,9S,10R,12S,13R,14S,17R)-7,12-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| Product Chemical Formula | C27H44O3 |
| Product PubChem CID | 3081958 |
| Product CAS Number | 1254-03-1 |
| Product Smiles | C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](CC4=CC(=O)CC[C@]34C)O)O)C |
| Product Structure |
References:
| Title: | The structure and characterization of human cytochrome P450 8B1 supports future drug design for nonalcoholic fatty liver disease and diabetes. |
| PMID: | 35944583 |
| Journal: | Journal of Biological Chemistry |
| Year: | 2022/9/ |