Detail Information

P450 Protein:

P450 SymbolCYP11B1
Protein NameCytochrome P450 11B1, mitochondrial
Uniprot IDP15150
EC Number1.14.15.4/1.14.15.5
SpeciesBos taurus
Txid 9913
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C21H30O4 + Fe2S2 + O2 + H+ → C21H28O4 + Fe2S2 + H2O
Reaction TypeOxidation
Chemical BondC-OH
RheaID 76439

19-Hydroxydeoxycorticosterone

+

[2Fe-2S]1+

+

O2

+

H+

CYP11B1

19-Oxo-deoxycorticosterone

+

[2Fe-2S]2+

+

H2O

Substrate Information:

Substrate Name 19-Hydroxydeoxycorticosterone
Substrate Chemical FormulaC21H30O4
Substrate PubChem CID164961
Substrate SmilesC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CO)CCC4=CC(=O)CC[C@]34CO
Substrate Structure
Substrate Name [2Fe-2S]1+
Substrate Chemical FormulaFe2S2
Substrate SmilesS1[Fe]S[Fe+]1
Substrate Structure
Substrate Name O2
Substrate Chemical FormulaO2
Substrate PubChem CID977
Substrate CAS Number7782-44-7
Substrate SmilesO=O
Substrate Structure
Substrate Name H+
Substrate Chemical FormulaH+
Substrate PubChem CID1038
Substrate CAS Number12408-02-5
Substrate Smiles[H+]
Substrate Structure

Product Information:

Product Name 19-Oxo-deoxycorticosterone
Product Chemical FormulaC21H28O4
Product PubChem CID173380
Product CAS Number75220-37-0
Product SmilesC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CO)CCC4=CC(=O)CC[C@]34C=O
Product Structure
Product Name [2Fe-2S]2+
Product Chemical FormulaFe2S2
Product SmilesS1[Fe+]S[Fe+]1
Product Structure
Product Name H2O
Product Chemical FormulaH2O
Product PubChem CID962
Product CAS Number7732-18-5
Product SmilesO
Product Structure

References:

Title: Molecular cloning and nucleotide sequence of DNA of mitochondrial cytochrome P-450(11 beta) of bovine adrenal cortex.
PMID: 3429448
Journal: J Biochem
Year: 1987/10/

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics