Detail Information

P450 Protein:

P450 SymbolCyp11b2
Protein NameCytochrome P450 11B2, mitochondrial
Uniprot IDP30099
EC Number1.14.15.4; 1.14.15.5
SpeciesRattus norvegicus
Txid 10116
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C21H30O5 + Fe2S2 + O2 + H+ → C21H30O6 + Fe2S2 + H2O
Reaction TypeOxidation
Chemical BondCH
RheaID 76019

Cortisol

+

[2Fe-2S]1+

+

O2

+

H+

Cyp11b2

18-Hydroxycortisol

+

[2Fe-2S]2+

+

H2O

Substrate Information:

Substrate Name Cortisol
Substrate Chemical FormulaC21H30O5
Substrate PubChem CID5754
Substrate SmilesC[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
Substrate Structure
Substrate Name [2Fe-2S]1+
Substrate Chemical FormulaFe2S2
Substrate SmilesS1[Fe]S[Fe+]1
Substrate Structure
Substrate Name O2
Substrate Chemical FormulaO2
Substrate PubChem CID977
Substrate CAS Number7782-44-7
Substrate SmilesO=O
Substrate Structure
Substrate Name H+
Substrate Chemical FormulaH+
Substrate PubChem CID1038
Substrate CAS Number12408-02-5
Substrate Smiles[H+]
Substrate Structure

Product Information:

Product Name 18-Hydroxycortisol
Product Chemical FormulaC21H30O6
Product PubChem CID44263343
Product SmilesC[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@]4(C(=O)CO)O)CO)O
Product Structure
Product Name [2Fe-2S]2+
Product Chemical FormulaFe2S2
Product SmilesS1[Fe+]S[Fe+]1
Product Structure
Product Name H2O
Product Chemical FormulaH2O
Product PubChem CID962
Product CAS Number7732-18-5
Product SmilesO
Product Structure

References:

Title: Cloning and expression of a rat cytochrome P-450 11 beta-hydroxylase/aldosterone synthase (CYP11B2) cDNA variant.
PMID: 8333830
Journal: Biochem Biophys Res Commun
Year: 1993/7/15

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics