Detail Information
P450 Protein:
| P450 Symbol | CYP5164A3 |
| Protein Name | Hydroperoxide bicyclase CYP5164A3, mitochondrial (EsHPB) (EC 4.2.1.-) (Cytochrome P450 5164A3) |
| Uniprot ID | D8LQS7 |
| EC Number | 4.2.1.- |
| Species | Ectocarpus siliculosus (Brown alga) (Conferva siliculosa) |
| Txid | 2880 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H29O4- → C20H27O3- + H2O |
| Reaction Type | Cyclization |
| Chemical Bond | C=C |
| RheaID | 75615 |
CYP5164A3
+
Substrate Information:
| Substrate Name | (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate |
| Substrate Chemical Formula | C20H29O4- |
| Substrate PubChem CID | 168007615 |
| Substrate Smiles | CCC=CCC(C=CC=CCC=CCC=CCCCC(=O)[O-])OO |
| Substrate Structure |
Product Information:
| Product Name | ectocarpin B |
| Product Chemical Formula | C20H27O3- |
| Product PubChem CID | 168007618 |
| Product Smiles | CC=CC1CC2C(C1C=CCC=CCC=CCCCC(=O)[O-])O2 |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
References:
| Title: | The Ectocarpus genome and the independent evolution of multicellularity in brown algae. |
| PMID: | 20520714 |
| Journal: | Nature |
| Year: | 2022/10/ |
| Title: | Lipoxygenase pathway in brown algae: The biosynthesis of novel oxylipins 'ectocarpins' by hydroperoxide bicyclase CYP5164A3 of Ectocarpus siliculosus. |
| PMID: | 35835431 |
| Journal: | Biochimica et biophysica acta. Molecular and cell biology of lipids |
| Year: | 2010/6/3 |