Detail Information
P450 Protein:
| P450 Symbol | CLM2 |
| Protein Name | Cytochrome P450 monooxygenase CLM2 (EC 1.-.-.-) (Culmorin biosynthesis protein 2) |
| Uniprot ID | A0A098D1J7 |
| EC Number | 1.-.-.- |
| Species | Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum) |
| Txid | 229533 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C15H26O + C17H21N4O9P-2 + O2 → C15H26O2 + C17H18N4O9P-3 + H2O + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| RheaID | 83903 |
+
+
CLM2
+
+
+
Substrate Information:
| Substrate Name | (-)-longiborneol |
| Substrate Chemical Formula | C15H26O |
| Substrate PubChem CID | 162623237 |
| Substrate Smiles | CC1(CCCC2(C3C1C(C2(CC3)C)O)C)C |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | culmorin |
| Product Chemical Formula | C15H26O2 |
| Product PubChem CID | 21119328 |
| Product Smiles | CC1(CCCC2(C3C1C(C2(CC3O)C)O)C)C |
| Product Structure |
| Product Name | FMN |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization. |
| PMID: | 17823352 |
| Journal: | Journal of natural products |
| Year: | 2015/7/22 |
| Title: | Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium. |
| PMID: | 20237561 |
| Journal: | Nature |
| Year: | 2010/1/ |
| Title: | The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum. |
| PMID: | 26198851 |
| Journal: | Applied and environmental microbiology |
| Year: | 2016/1/22 |
| Title: | CLM1 of Fusarium graminearum encodes a longiborneol synthase required for culmorin production. |
| PMID: | 19880637 |
| Journal: | Science (New York, N.Y.) |
| Year: | 2010/3/18 |
| Title: | Hydroxylation of Longiborneol by a Clm2-Encoded CYP450 Monooxygenase to Produce Culmorin in Fusarium graminearum. |
| PMID: | 26673640 |
| Journal: | BMC genomics |
| Year: | 2007/9/7 |