Detail Information
P450 Protein:
| P450 Symbol | dabD |
| Protein Name | N-geranyl-L-glutamate oxidase (EC 1.14.14.-) (Domoic acid biosynthesis cluster protein D) (PmDabD) |
| Uniprot ID | A0A386KZI3 |
| EC Number | 1.14.14.- |
| Species | Pseudo-nitzschia multiseries (Marine planktonic diatom) (Nitzschia pungens f. multiseries) |
| Txid | 37319 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C15H24NO5- + C17H21N4O9P-2 + O2 → C15H22NO5- + C17H18N4O9P-3 + H2O + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| RheaID | 68164 |
+
+
dabD
+
+
+
Substrate Information:
| Substrate Name | N-(8′-hydroxygeranyl)-L-glutamate |
| Substrate Chemical Formula | C15H24NO5- |
| Substrate PubChem CID | 145864987 |
| Substrate Smiles | CC(=CC[NH2+]C(CCC(=O)[O-])C(=O)[O-])CCC=C(C)CO |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | N-(8′-oxogeranyl)-L-glutamate |
| Product Chemical Formula | C15H22NO5- |
| Product PubChem CID | 145865083 |
| Product Smiles | CC(=CC[NH2+]C(CCC(=O)[O-])C(=O)[O-])CCC=C(C)C=O |
| Product Structure |
| Product Name | FMN |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom. |
| PMID: | 30262498 |
| Journal: | Science (New York, N.Y.) |
| Year: | 1998/1/ |
| Title: | The activation of glutamate receptors by kainic acid and domoic acid. |
| PMID: | 10223631 |
| Journal: | Natural toxins |
| Year: | 2018/9/28 |