Detail Information
P450 Protein:
| P450 Symbol | GO |
| Protein Name | Geissoschizine oxidase (SpGO) (EC 1.14.19.80) (CYP450 monooxygenase GO) (Cytochrome P450 GO) |
| Uniprot ID | P0DO88 |
| EC Number | 1.14.19.80 |
| Species | Strychnos sp |
| Txid | 2946199 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C21H23N2O3+ → C21H23N2O3+ |
| Reaction Type | Rearrangement |
| Chemical Bond | |
| RheaID | 79587 |
GO
Substrate Information:
| Substrate Name | 3,17-didehydrostemmadenine |
| Substrate Chemical Formula | C21H23N2O3+ |
| Substrate PubChem CID | 171904539 |
| Substrate Smiles | CC=C1C[N+]2=CCC1C(C3=C(CC2)C4=CC=CC=C4N3)(C=O)C(=O)OC |
| Substrate Structure |
Product Information:
| Product Name | 17-dehydropreakuammicine |
| Product Chemical Formula | C21H23N2O3+ |
| Product PubChem CID | 135398072 |
| Product Smiles | CC=C1C[NH+]2CCC34C2CC1C(C3=NC5=CC=CC=C45)(C=O)C(=O)OC |
| Product Structure |
References:
| Title: | Biosynthesis of strychnine. |
| PMID: | 35794473 |
| Journal: | Nature |
| Year: | 2022/7/ |