Detail Information
P450 Protein:
| P450 Symbol | CYP512U6 |
| Protein Name | Cytochrome P450 monooxygenase CYP512U6 (EC 1.-.-.-) |
| Uniprot ID | A0A346B546 |
| EC Number | 1.-.-.- |
| Species | Ganoderma lucidum (Ling zhi medicinal fungus) (Bracket fungus) |
| Txid | 5315 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C30H43O5- + C17H21N4O9P-2 + O2 → C30H43O6- + C17H18N4O9P-3 + H2O + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| RheaID | 68732 |
+
+
CYP512U6
+
+
+
Substrate Information:
| Substrate Name | ganoderate DM |
| Substrate Chemical Formula | C30H43O5- |
| Substrate PubChem CID | 156587286 |
| Substrate Smiles | CC(CCC=C(C)C(=O)[O-])C1CC(C2(C1(CCC3=C2C(=O)CC4C3(CCC(=O)C4(C)C)C)C)C)O |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | hainanate A |
| Product Chemical Formula | C30H43O6- |
| Product PubChem CID | 156587288 |
| Product Smiles | CC(CC(C=C(C)C(=O)[O-])O)C1CC(C2(C1(CCC3=C2C(=O)CC4C3(CCC(=O)C4(C)C)C)C)C)O |
| Product Structure |
| Product Name | FMN |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast. |
| PMID: | 30077898 |
| Journal: | Phytochemistry |
| Year: | 2018/11/ |